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Glucophage

  • $0.17
  • Availability: In Stock
  • Active Ingredient metformin
Glucophage is an oral diabetes medicine used to treat type 2 of diabetes.
Analogs of Glucophage: Metformin   Actoplus Met   Glycomet  
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Other names of Glucophage: a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Actos Met   Adglim-M   Aglikem   Alexodiab   Amaryl m   Amaryl M Forte   Amaryl M SR   Amophage   Andibet   Anglucid   Anhe   Asegur   Asoformin   Asoformin-P   Asoride-M   Avandamet   Accord Metformin   Actomeg   ActoPlus met XR   Actos M   Actosmet   Adecco   Adimet   Adride-M   Agimfor   Aglumet   Aglurab   Amaryl Combi   Amaryl XM   Ammiformin   Andm   Anformin   Ankomin   Ansures   Ansures ER   Antigluco   Anxofin   Anxoken   Apo-Metformin   Aromet   Arrow Metformine HCL   Asformin   Austell-Metformin   Avamina   Azulix-MF  
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500 mg
Product name Per Pill Per Pack  
90 pills $0.34 $30.78
120 pills $0.29 $41.04 $34.33
180 pills $0.23 $61.56 $41.45
240 pills $0.20 $82.08 $48.58
360 pills $0.17 $123.12 $62.78
850 mg
Product name Per Pill Per Pack  
90 pills $0.42 $37.69
180 pills $0.28 $75.38 $50.26
270 pills $0.23 $113.08 $62.80
360 pills $0.21 $150.77 $75.38

Product Description

Common use

Glucophage is an oral diabetes medicine used to treat type 2 of diabetes. Its active substance is Metformin which belongs to biguanide class of substances. It reduces concentration of glucose in blood suppressing metabolism of glucose in the liver, reducing absorption of glucose from the gastrointestinal tract, and enhancing its utilization in tissues. Glucophage stabilizes or reduces body weight. The therapeutic effect is not observed in the absence of insulin in the blood. It does not cause hypoglycemic reactions. It improves fibrinolytic properties of blood. It is used to treat diabetes mellitus (type 2) in adults also in patients for whom the treatment with sulfonylurea was ineffective, especially in cases followed by obesity.

Dosage and direction

Do not take if this medication was not prescribed to you and do not exceed the recommended dose. Take it with a meal if your doctor did not recommend you to take it differently. Glucophage is administered for taking twice daily by 500 mg or 850 mg once daily to treat type 2 diabetes in adults. Basing on the glucose levels in the blood the dose of Glucophage can be increased to the maximum daily dose of 2550 mg given in three divided doses.

Precautions

This medication is able to cause a life threatening condition in some people which is characterized by weakness, increasing sleepiness, slow heartbeat, cold feeling, muscle pain, abdominal pain, shortness of breath, feeling light-headed, and fainting. It is called lactic acidosis. If you experience such symptoms get immediate medical attention. Also be attentive to symptoms of low blood sugar which include hunger, confusion, irritability, drowsiness, headache, weakness, fast heartbeat, tremors, sweating, seizure and have a source of sugar at hand always. Avoid drinking alcohol.

Contraindications

Hypersensitivity, hyperglycemic coma, ketoacidosis, kidney failure, liver disease, heart failure, acute myocardial infarction, respiratory failure, dehydration, infectious diseases, extensive surgery and trauma, alcoholism, reduced-calorie diet (less than 1000 kcal / day), lactic acidosis (including history), pregnancy, breastfeeding. The drug is not prescribed to take 2 days before a surgery, radioisotope and X-ray examinations, CAT scanning (CT). Glucophage is contraindicated in patients over 60 y.o., or doing hard physical work (risk of lactic acidosis increases).

Side effects

The following side effects are most common and rather severe to stop taking the medication: swelling or rapid weight gain, nausea, vomiting, gas, bloating, diarrhea and loss of appetite. In case of lactic acidosis get emergency medical help: weakness, increasing drowsiness, slow heartbeat, cold feeling, shortness of breath, abdominal pain, muscle pain, lightheadedness, and fainting. Allergic reaction is also possible: hives, swelling, rash.

Drug interaction

Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or time for your next dose is in a short while. Do not take double doses of this medication or extra doses of it. Take your usual dose next day in the same regular time.

Overdose

Symptoms of Glucophage overdose are ones of low blood sugar: hunger, confusion, irritability, drowsiness, headache, weakness,, tremors, sweating, fast heartbeat, seizure. Do not forget to have a source of sugar at hand always. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store it in a bathroom and places available for children.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Purchasing medications online is quite risky, as you are in charge of the safety and effectiveness of the therapy, to some extent. At the same time, everything remains simple and clear – following the recommendations and safety instructions is the key to a flawless and successful course. However, be aware of the following side effects that may appear if you misuse the drug:

Rare

  • Behavior change similar to being drunk
  • difficulty with concentrating
  • drowsiness
  • lack or loss of strength
  • restless sleep
  • unusual sleepiness

More Common

  • Abdominal or stomach discomfort
  • cough or hoarseness
  • decreased appetite
  • diarrhea
  • fast or shallow breathing
  • fever or chills
  • general feeling of discomfort
  • lower back or side pain
  • muscle pain or cramping
  • painful or difficult urination
  • sleepiness
  • Acid or sour stomach
  • belching
  • bloated
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • loss of appetite
  • metallic taste in the mouth
  • passing of gas
  • stomachache
  • stomach upset or pain
  • vomiting
  • weight loss

Less Common

  • Anxiety
  • blurred vision
  • chest discomfort
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • difficult or labored breathing
  • dizziness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • headache
  • increased hunger
  • increased sweating
  • nausea
  • nervousness
  • nightmares
  • redness of the face, neck, arms, and occasionally, upper chest
  • seizures
  • shakiness
  • shortness of breath
  • slurred speech
  • tightness in the chest
  • unusual tiredness or weakness
  • Abnormal stools
  • bad, unusual, or unpleasant (after) taste
  • change in taste
  • difficulty with moving
  • discoloration of the fingernails or toenails
  • flu-like symptoms
  • joint pain
  • metallic taste in mouth
  • rash
  • runny nose
  • sneezing
  • stuffy nose
  • swollen joints
Type Small Molecule
Accession Number DB00331  (APRD01099)
Groups Approved
Synonyms
  • 1,1-Dimethylbiguanide
  • Dimethylbiguanid
  • Metformin
  • Metformina
  • Metformine
  • Metforminum
UNII 9100L32L2N
CAS number 657-24-9
Weight Average: 129.1636
Monoisotopic: 129.101445377
Chemical Formula C4H11N5
InChI
InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
IUPAC Name
1-carbamimidamido-N,N-dimethylmethanimidamide
Protein binding

Metformin is negligibly bound to plasma proteins.

Toxicity

Acute oral toxicity (LD50): 350 mg/kg Rabbit. It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.

Half life

6.2 hours. Duration of action is 8-12 hours.

We are always expanding our borders, offering customers only the best services and the most convenient options. Currently, we are proud of international delivery, which is both fast and quality. The shipping time will not exceed 14 days, but can be considerably shorter, which depends mainly on the destination. Here is a list of Indian cities we ship medications to:

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