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Cymbalta

  • $0.70
  • Availability: In Stock
  • Active Ingredient Duloxetine
Cymbalta heals depression, relieves peripheral neuropathic pains associated with diabetes.
Analogs of Cymbalta: Malegra DXT   Malegra DXT Plus  
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Other names of Cymbalta: a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Ariclaim   Alacir   Ambidext   Ariclaim   Ao Si Ping   APO-Duloxetine   Aritavi  
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40 mg
Product name Per Pill Per Pack  
30 pills $2.75 $82.54
60 pills $1.98 $165.07 $118.64
90 pills $1.72 $247.61 $154.76
120 pills $1.59 $330.14 $190.86
180 pills $1.46 $495.22 $263.09
270 pills $1.38 $742.82 $371.41
30 mg
Product name Per Pill Per Pack  
30 pills $2.52 $75.59
60 pills $1.78 $151.19 $106.96
90 pills $1.54 $226.78 $138.34
120 pills $1.41 $302.38 $169.70
180 pills $1.29 $453.56 $232.45
270 pills $1.21 $680.35 $326.57
20 mg
Product name Per Pill Per Pack  
30 pills $1.53 $45.86
60 pills $1.08 $91.73 $64.71
90 pills $0.93 $137.59 $83.56
120 pills $0.85 $183.46 $102.41
180 pills $0.78 $275.18 $140.09
270 pills $0.73 $412.78 $196.64
360 pills $0.70 $550.37 $253.19
60 mg
Product name Per Pill Per Pack  
30 pills $3.38 $101.53
60 pills $2.66 $203.06 $159.66
90 pills $2.42 $304.60 $217.78
120 pills $2.30 $406.13 $275.92
180 pills $2.18 $609.19 $392.17
270 pills $2.10 $913.79 $566.54

Product Description

Common use

Duloxetine belongs to the class of serotonin-norepinephrine reuptake inhibitors (SNRIs). Duloxetine is used to treat major depressive disorder or generalized anxiety disorder. It also helps to lessen pain associated with diabetic neuropathy and fibromyalgia.

Dosage and direction

Take Cymbalta by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine.
Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor.
Consult your doctor concerning proper dose for you.

Precautions

Before taking Cymbalta tell your doctor or chemist if you are allergic to Duloxetine; or if you have other allergies.
Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems.
Aged people can be more sensitive to side effects of the medicine.
During the pregnancy this treatment should be used only when strongly necessary.
As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications

Cymbalta should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Duloxetine.

Possible side effect

The most common side effects are quick and irregular pulse, tremor, anxiety, blurred vision, vomiting, fever, diarrhea, etc.
A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects.
Turn to your doctor or pharmacist for more details.
In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction

Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication.
Duloxetine can interact with:
* MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc.
* Antiarrhythmic drugs: Propafenone, Quinidine, etc
* Selective serotonin reuptake inhibitors (SSRIs): Citalopram, Dapoxetine, Fluoxetine, Fluvoxamine, Paroxetine, etc.
* Antipsychotics (also called neuroleptics): Fluphenazine, etc.
* H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc.
Turn to your doctor or pharmacist for more details.

Missed dose

If you have missed your dose, take it as soon as you remember. If you see that it is practically the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose

If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage

Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store them in the bathroom. Keep all drugs away from children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Purchasing medications online is quite risky, as you are in charge of the safety and effectiveness of the therapy, to some extent. At the same time, everything remains simple and clear – following the recommendations and safety instructions is the key to a flawless and successful course. However, be aware of the following side effects that may appear if you misuse the drug:

More Common

  • Body aches or pain
  • cough
  • difficulty having a bowel movement (stool)
  • dry mouth
  • ear congestion
  • frequent urination
  • headache
  • lack or loss of strength
  • loss of appetite
  • loss of voice
  • muscle aches
  • nausea
  • sleepiness or unusual drowsiness
  • sneezing
  • sore throat
  • stuffy or runny nose
  • sweating increased
  • trouble sleeping
  • weight loss

Less Common

  • Abnormal orgasm
  • acid or sour stomach
  • belching
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • change or problem with discharge of semen
  • decreased interest in sexual intercourse
  • difficulty with moving
  • feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • joint pain
  • longer than usual time to ejaculation of semen
  • loose stools
  • loss in sexual ability, desire, drive, or performance
  • loss of taste
  • muscle aching or cramping
  • muscle pains or stiffness
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort or upset
  • sudden sweating
  • swollen joints
  • trembling or shaking of the hands or feet

Incidence Not Known

  • Abdominal or stomach pain
  • area rash
  • blindness
  • blistering, peeling, or loosening of the skin
  • blurred vision
  • change in consciousness
  • chills
  • clay-colored stools
  • cold sweats
  • confusion
  • convulsions
  • dark urine
  • decreased urine output
  • decreased vision
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • eye pain
  • fainting
  • fast or irregular heartbeat
  • general tiredness or weakness
  • hives or welts, itching, or skin rash
  • hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue
  • increased thirst
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • loss of consciousness
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • sores, ulcers, or white spots in the mouth or on the lips
  • swelling of the face, ankles, or hands
  • tearing
  • tightness in the chest
  • unpleasant breath odor
  • upper right stomach pain
  • vomiting of blood
  • yellow eyes and skin
Type Small Molecule
Accession Number DB00476  (APRD00060)
Groups Approved
Synonyms
  • (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine
  • (S)-duloxetine
UNII O5TNM5N07U
CAS number 116539-59-4
Weight Average: 297.415
Monoisotopic: 297.118734925
Chemical Formula C18H19NOS
InChI
InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
IUPAC Name
methyl[(3S)-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl]amine
Protein binding

Protein binding is greater than 90%.

Toxicity

Oral, rat LD50: 491 mg/kg for males and 279 mg/kg for females. Symptoms of overdose include tremors, convulsions, reduced activity, slow pupillary response, intermittent tremors, and rigidity.

Half life

12 hours (range 8-17 hours)

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